Mega Mewtwo Y is one of the most effective users of No Guard OHKO moves thanks to its high Speed, high Special Attack, and ability to catch opponents off-guard thanks to its wide array of other viable sets. Choice Scarf allows Mega Mewtwo Y to outspeed every unboosted threat as well as some boosted ones, such as +2 maximum Speed Primal Groudon. Sheer Cold is the preferred OHKO move, as no Pokemon is immune to it without Wonder Guard or Sturdy. Fissure is an alternative that misses out on Mega Rayquaza, Yveltal, and Ho-Oh but hits the somewhat uncommon, though still relevant, group of Wonder Guard users weak to Ground—namely Primal Groudon, Mega Lucario, and Mega Manectric. Trick allows Mega Mewtwo Y to both hinder a Wonder Guard switch-in and have the flexibility of switching moves for the remainder of the game. Choice Scarf No Guard Mega Mewtwo Y's remaining two moveslots are extremely flexible, and almost any combination of the listed moves is viable. Sing, Gastro Acid, and Stealth Rock take advantage of Mega Mewtwo Y's ability to force in Wonder Guard users with Sheer Cold or Fissure, either hindering them with sleep, forcing them to switch out again, or taking advantage of the forced switch by setting Stealth Rock. Sing and Gastro Acid together allow Mega Mewtwo Y to spread sleep and generate an abundance of free turns for its teammates. Gastro Acid also pairs nicely with Stealth Rock, allowing Mega Mewtwo Y to continually force chip damage against Wonder Guard foes. Alternatively, thanks to Mega Mewtwo Y's extremely high Special Attack stat, it can effectively run coverage moves to damage or outright KO common Wonder Guard switch-ins. Zap Cannon and Inferno hit Water- and Bug / Steel type Wonder Guard users, respectively, in addition to being broadly useful against a wide-array of non-Wonder Guard threats thanks to their respective 100% chances to paralyze and burn. Additionally, Zap Cannon 2HKOes Mold Breaker Mega Rayquaza, non-Assault Vest Yveltal, and Ho-Oh after minimal chip—making it particularly useful on Fissure variants of Mega Mewtwo Y. Freeze-Dry hits Water-type Wonder Guard users, Giratina, and OHKOes the most relevant Flying-type, Mega Rayquaza, making it another useful option on Fissure variants of Mega Mewtwo Y. Sludge Wave hits common Fairy-type Wonder Guard users like Xerneas, Mega Audino, and Mega Gardevoir, while Focus Blast threatens Normal-type Wonder Guard users not named Blissey or Chansey. The leftover 4 EVs should be placed in Defense to allow Mega Mewtwo Y to always survive Mega Diancie's Pursuit. Note that if Mega Mewtwo Y opts to forgo coverage attacks completely, an EV spread of 248 HP / 8 Def / 252 Spe and a Timid nature should be used.
Most teams benefit from the revenge killing potential Choice Scarf No Guard Mega Mewtwo Y provides, in addition to forcing in passive Wonder Guard users that teammates can take advantage of. Due to Mega Mewtwo Y's frailty, slow Wonder Guard pivots, such as Xerneas and Mega Scizor, make good teammates. In particular, Substitute + Baton Pass teammates like Wonder Guard Xerneas can grant Mega Mewtwo Y security against revenge killers and Imposter users. In return, Mega Mewtwo Y provides them with free turns to create and pass Substitutes to other teammates as well. Powerful offensive Pokemon such as Choice Band Mold Breaker Primal Groudon and Mega Rayquaza appreciate No Guard Mega Mewtwo Y's ability to force in Wonder Guard users. Additionally, both Wonder Guard and Mold Breaker setup sweepers appreciate the free turns Mega Mewtwo Y generates, as well as its ability to threaten Prankster Giratina; however, Giratina can force a trade with Destiny Bond. Trick-immune Wonder Guard teammates such as Blue Orb Primal Kyogre, Plate Arceus, and Mail Cresselia are valuable teammates to Imposter-proof No Guard + Trick Mega Mewtwo Y. Shadow Tag teammates such as Mega Mewtwo X and Perish Song Lugia appreciate Mega Mewtwo Y's ability to force in Wonder Guard users and remove their Shed Shell with Trick. Wonder Guard users with Stealth Rock, Defog, and Aromatherapy are also notable teammates for Gastro Acid variants of Mega Mewtwo Y, as they help it continually force switches—and entry hazard chip damage—versus opposing Wonder Guard and Mold Breaker users alike, while also allowing Mega Mewtwo Y to switch freely without fear of entry hazard chip damage itself. Finally, -ate Speed users make excellent teammates for Choice Scarf No Guard Mega Mewtwo Y, as they can revenge kill nearly every boosted threat that Mega Mewtwo Y itself doesn’t outpace and revenge kill.