Moves
Will-O-Wisp can be used to cripple the physical attackers that Misdreavus switches into, such as Tauros and Kabutops, while also inflicting chip damage and boosting Hex's power to respectable levels. Hex inflicts decent damage to most Pokemon that are not Normal-types if they have been burned or inflicted with status by a teammate or Toxic Spikes; it does enough damage to prevent Misdreavus from being too passive. Foul Play is a good option to hit Normal-types such as Tauros directly, giving Misdreavus a better matchup against some of the specific targets it can check. It also does good damage to physical setup sweepers, such as Swords Dance Samurott and Shell Smash Barbaracle, dissuading these faster threats that could avoid a Taunt from setting up if necessary. Pain Split is Misdreavus's best recovery move and can also inflict chip damage on foes, being most effective against targets with high HP, such as Lanturn, Audino, and Aurorus. Taunt can be used to stop setup attempts from slower threats such as Mega Audino, block entry hazard moves from Steelix and defensive Omastar, and protect Misdreavus against status attacks such as Steelix's and Quagsire's Toxic. Thunder Wave can also be used to punish Fire-types that try to switch into Will-O-Wisp, as well as special attackers that don't mind a burn and faster targets such as Archeops in general.
Set Details
56 Speed EVs are used to outspeed maximum Speed neutral-natured Pawniard, Torterra, and Aurorus, while the remaining EVs are invested in HP and Defense to improve Misdreavus's physical bulk as much as possible, emphasizing its niche over Mismagius as a bulky spinblocker. An EV spread of 252 HP / 240 Def / 16 Spe with a Timid nature can be used to outspeed maximum Speed Adamant Sandslash as well as positive-natured Golurk and Omastar, while 96 Speed EVs and a Timid nature allow Misdreavus to outspeed maximum Speed neutral-natured Samurott, Hitmonchan, Garbodor, and most Skuntank and Xatu variants. Outspeeding Skuntank will generally allow Misdreavus to win against it one-on-one even if it runs a Lum Berry, so consider whether the loss in bulk is worth the opportunity to outspeed and Taunt or inflict status on a wider range of targets before they can move. Levitate is useful for dodging Earthquakes from Rhydon, Steelix, and Torterra and lets Misdreavus ignore Spikes and Toxic Spikes; the latter gives Misdreavus a solid niche over Gourgeist-XL. Eviolite is mandatory for the extra bulk it provides Misdreavus with and also allows it to tank strong special attacks such as Life Orb Haunter's Shadow Ball after Stealth Rock despite a lack of investment in Special Defense.
Usage Tips
Misdreavus should switch into Rapid Spin users, such as Hitmonchan and Kabutops, whenever they try to remove entry hazards, as well as physical attackers such as Tauros and Primeape that struggle to hit it hard. While Rotom and Mismagius take significant amounts of damage from a Life Orb-boosted Ice Punch from Hitmonchan or Waterfall from Kabutops, Misdreavus can tank those hits, making it a more consistent spinblocker than most other fast Ghost-types. It can then use Will-O-Wisp to burn them or another foe if they switch out or use Pain Split to heal up if it's significantly weakened. Misdreavus can switch in and Taunt threats such as Calm Mind Musharna and Mega Audino to stop them from setting up; it can also make for a good lead against slower entry hazard setters, such as defensive Omastar and Garbodor, by outspeeding them and using Taunt, thus forcing them to attack or switch out. Misdreavus can also use Taunt to block Defog from slow users, such as Pelipper and Mantine, giving it even more utility in keeping its team's entry hazards up. Even Lum Berry Skuntank can be beat with Taunt unless it runs Crunch, as Pursuit inflicts minimal damage to Misdreavus if it stays in and Sucker Punch can easily be bypassed by using Will-O-Wisp or Pain Split. Knock Off users, such as Hariyama and Zangoose, should be avoided at all costs, as the move will deal significant damage even from a burned target and will severely hinder Misdreavus's ability to take hits for the rest of the match.
Team Options
As Misdreavus is one of the most consistent spinblockers around, teammates that use Stealth Rock, Spikes, and Toxic Spikes highly appreciate its support. Toxic Spikes users such as Garbodor and Omastar synergize particularly well with it, as they appreciate Misdreavus's immunities to Ground- and Fighting-type moves, respectively, while Misdreavus enjoys the boosted Hex damage on poisoned targets. These two Pokemon can also provide Spikes support to wear down offensive Pokemon that Misdreavus can switch into repeatedly, such as Tauros and Primeape. Meanwhile, Omastar, Steelix, and Rhydon can use Stealth Rock and similarly appreciate Misdreavus's immunities. Strong cleaners, such as Kangaskhan and Swellow, appreciate Misdreavus's ability to spread residual damage, both through status and through the entry hazards it protects, and they can both beat opposing Ghost-types with their Scrappy STAB attacks. They can also reduce the opponent's opportunities for using Defog through the offensive pressure they provide. Fire-types, such as Pyroar, Magmortar, and Charizard, can usually switch into Misdreavus without fear, so packing a solid Pokemon that resists Fire-type moves, such as Hariyama, Grumpig, or Lanturn, is highly recommended, with the latter also potentially providing Heal Bell support to remove crippling status from Misdreavus. These Pokemon can also check other special attackers such as Floatzel and Manectric, which aren't too bothered by a burn from Misdreavus. Finally, having a dedicated switch-in to Knock Off is highly beneficial given Misdreavus's huge weakness to the move; Mega Audino can fill the role while also providing Wish and Heal Bell support, while bulky itemless Charizard is another option.